Brief Information of the Compound and Protein
Compound Name
(3S)-3-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-5,6,7,8-tetrahydro-4H-benzo[f]indazol-5-yl]-3-hydroxypropanenitrile
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Canonical SMILES
C[C@]12Cc3cnn(c3C=C1CCC[C@@H]2[C@@H](O)CC#N)-c1ccc(F)cc1
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Compound Formula C21H22FN3O
Compound Structure
Protein Name
Glucocorticoid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
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Nuclear hormone receptor subfamily 3
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Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 1
Uniprot ID
P06536
Gene Name
NR3C1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000230 INS-1 832/13 Rattus norvegicus (Rat)  2
1
EC50 = 2511.89 nM
   TI
   LI
   LO
   TS
2
IC50 = 1584.89 nM
   TI
   LI
   LO
   TS