Brief Information of the Compound and Protein
Compound Name
2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one
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PubChem ID
CID: 3749
SID: 12014641
Canonical SMILES
CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
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Compound Formula C25H28N6O
Compound Structure
Protein Name
Type-1 angiotensin II receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Angiotensin receptor
Uniprot ID
P30556
Gene Name
AGTR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
IC50 = 6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 20.8 nM
2 Ki = 0.8 nM
3 Ki = 1.1 nM