Brief Information of the Compound and Protein
Compound Name
 Compound Info 
BARICITINIB
    Show/Hide
 PubChem ID
CID: 44205240
SID: 85205106
Canonical SMILES
CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
    Show/Hide
Compound Formula C16H17N7O2S
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase JAK2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
O60674
Gene Name
JAK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000131 HEK293-F
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 0.29 nM
   TI
   LI
   LO
   TS
CL000128 TF-1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.8 nM
2 IC50 = 5.7 nM
3 IC50 = 6 nM
4 IC50 = 6.6 nM
5 IC50 = 7 nM
6 IC50 = 88 nM