Brief Information of the Compound and Protein
Compound Name
3-[(4S)-2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-N-(5-chloropyridin-2-yl)-4-fluorobenzamide
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Canonical SMILES
C[C@]1(CCSC(N)=N1)c1cc(ccc1F)C(=O)Nc1ccc(Cl)cn1
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Compound Formula C17H16ClFN4OS
Compound Structure
Protein Name
Beta-secretase 1
Protein Classification
Enzyme
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Protease
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Aspartic protease
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Aspartic protease AA clan
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Aspartic protease A1A subfamily
Uniprot ID
P56817
Gene Name
BACE1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000004 SH-SY5Y Homo sapiens (Human)  1
1
IC50 = 0.84 nM
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