Brief Information of the Compound and Protein
Compound Name
(S)-N4-(3-Ethyl-1H-pyrazol-5-yl)-N2-(1-(5-fluoropyridin-2-yl)-ethyl)-5-methylquinazoline-2,4-diamine
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Canonical SMILES
CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(C)c23)n[nH]1
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Compound Formula C21H22FN7
Compound Structure
Protein Name
G protein-coupled receptor kinase 6
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
AGC protein kinase group
>
AGC protein kinase GRK family
>
AGC protein kinase GRK subfamily
Uniprot ID
P43250
Gene Name
GRK6
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000559 KMS-11 Homo sapiens (Human)  1
1
IC50 = 610 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 11 nM