Brief Information of the Compound and Protein
Compound Name
4-N-(5-ethyl-1H-pyrazol-3-yl)-2-N-[(5-fluoropyridin-2-yl)methyl]-5-methoxyquinazoline-2,4-diamine
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Canonical SMILES
CCc1cc(Nc2nc(NCc3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1
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Compound Formula C20H20FN7O
Compound Structure
Protein Name
G protein-coupled receptor kinase 6
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
AGC protein kinase group
>
AGC protein kinase GRK family
>
AGC protein kinase GRK subfamily
Uniprot ID
P43250
Gene Name
GRK6
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000559 KMS-11 Homo sapiens (Human)  1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 18 nM
2 IC50 = 33 nM