Brief Information of the Compound and Protein
Compound Name
1-[4-[[4-[1-cyclopropyl-3-(3,3-difluorocyclobutyl)pyrazol-4-yl]oxypyridin-2-yl]amino]pyridin-2-yl]-4,4-difluorocyclohexan-1-ol
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Canonical SMILES
OC1(CCC(F)(F)CC1)c1cc(Nc2cc(Oc3cn(nc3C3CC(F)(F)C3)C3CC3)ccn2)ccn1
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Compound Formula C26H27F4N5O2
Compound Structure
Protein Name
TGF-beta receptor type-1
Protein Classification
Enzyme
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Kinase
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Protein Kinase
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TKL protein kinase group
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TKL protein kinase STKR family
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TKL protein kinase STKR Type 1 subfamily
Uniprot ID
Q64729
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3 Mus musculus (Mouse)  1
1
IC50 = 57.1 nM
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