Brief Information of the Compound and Protein
Compound Name
2-(3-fluorophenyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-1,7-naphthyridin-8-amine
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Canonical SMILES
Nc1ncc(-c2cnn(c2)C2CCNCC2)c2ccc(nc12)-c1cccc(F)c1
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Compound Formula C22H21FN6
Compound Structure
Protein Name
Mitogen-activated protein kinase kinase kinase kinase 3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
>
STE protein kinase STE20 family
>
STE protein kinase KHS subfamily
Uniprot ID
Q8IVH8
Gene Name
MAP4K3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 490 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12 nM