Brief Information of the Compound and Protein
Compound Name
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
    Show/Hide
PubChem ID
CID: 11626560
SID: 16729581
Canonical SMILES
C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
    Show/Hide
Compound Formula C21H22Cl2FN5O
Compound Structure
Protein Name
Mitogen-activated protein kinase kinase kinase kinase 3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
>
STE protein kinase STE20 family
>
STE protein kinase KHS subfamily
Uniprot ID
Q8IVH8
Gene Name
MAP4K3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 49 nM
2 Kd = 75 nM