Brief Information of the Compound and Protein
Compound Name
4-amino-N-[6-chloro-3-[(2,5-difluorophenyl)sulfonylamino]-2-fluorophenyl]quinazoline-8-carboxamide
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Canonical SMILES
Nc1ncnc2c(cccc12)C(=O)Nc1c(Cl)ccc(NS(=O)(=O)c2cc(F)ccc2F)c1F
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Compound Formula C21H13ClF3N5O3S
Compound Structure
Protein Name
Serine/threonine-protein kinase/endoribonuclease IRE1
Protein Classification
Enzyme
Uniprot ID
O75460
Gene Name
ERN1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12700 nM