Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-5-oxopyrrolidine-2-carboxamide
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 PubChem ID
CID: 23649427
SID: 46521018
Canonical SMILES
CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F
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Compound Formula C14H14ClF3N2O2
Compound Structure
Protein Name
 Protein Info 
P2X purinoceptor 7
Protein Classification
Ion channel
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Ligand-gated ion channel
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P2X receptor
Uniprot ID
Q99572
Gene Name
P2RX7
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  5
1
IC50 = 3.162 nM
   TI
   LI
   LO
   TS
2
IC50 = 20 nM
   TI
   LI
   LO
   TS
3
IC50 = 119.3 nM
   TI
   LI
   LO
   TS
4
IC50 = 332.4 nM
   TI
   LI
   LO
   TS
5
Ki = 68 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3.162 nM