Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[4-[1-cyclopropyl-3-(oxan-4-yl)pyrazol-4-yl]oxypyridin-2-yl]-2-(4-propan-2-ylpiperazin-1-yl)pyridin-4-amine
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 PubChem ID
CID: 156010511
Canonical SMILES
CC(C)N1CCN(CC1)c1cc(Nc2cc(Oc3cn(nc3C3CCOCC3)C3CC3)ccn2)ccn1
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Compound Formula C28H37N7O2
Compound Structure
Protein Name
 Protein Info 
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 54.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 13 nM