Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[1-cyclopropyl-3-(oxan-4-yl)pyrazol-4-yl]oxy-N-[1-[(3-methyloxetan-3-yl)methyl]pyrazol-4-yl]pyridin-2-amine
    Show/Hide
 PubChem ID
CID: 156019751
Canonical SMILES
CC1(Cn2cc(Nc3cc(Oc4cn(nc4C4CCOCC4)C4CC4)ccn3)cn2)COC1
    Show/Hide
Compound Formula C24H30N6O3
Compound Structure
Protein Name
 Protein Info 
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 338 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 32 nM