Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[[4-[1-cyclopropyl-3-(oxan-4-yl)pyrazol-4-yl]oxypyridin-2-yl]amino]-2-(3-hydroxy-3-methylazetidin-1-yl)benzonitrile
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 PubChem ID
CID: 152401836
Canonical SMILES
CC1(O)CN(C1)c1cc(Nc2cc(Oc3cn(nc3C3CCOCC3)C3CC3)ccn2)ccc1C#N
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Compound Formula C27H30N6O3
Compound Structure
Protein Name
 Protein Info 
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 85.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 14 nM