Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-N-[4-[1-cyclopropyl-3-(oxan-4-yl)pyrazol-4-yl]oxypyridin-2-yl]-2-N-(oxan-4-yl)pyridine-2,4-diamine
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 PubChem ID
CID: 156020478
Canonical SMILES
C1CC1n1cc(Oc2ccnc(Nc3ccnc(NC4CCOCC4)c3)c2)c(n1)C1CCOCC1
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Compound Formula C26H32N6O3
Compound Structure
Protein Name
 Protein Info 
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 133.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 17 nM