Brief Information of the Compound and Protein
Compound Name
9-(4,4-difluorocyclohexyl)-7-methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]purin-8-one
    Show/Hide
PubChem ID
CID: 155521367
Canonical SMILES
Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCC(F)(F)CC3)c2n1
    Show/Hide
Compound Formula C19H20F2N8O
Compound Structure
Protein Name
DNA-dependent protein kinase catalytic subunit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
Atypical protein kinase group
>
Atypical protein kinase PIKK family
Uniprot ID
P78527
Gene Name
PRKDC
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 50.12 nM
   TI
   LI
   LO
   TS
CL000017 HeLa Homo sapiens (Human)  1
1
IC50 = 0.1995 nM
   TI
   LI
   LO
   TS