Brief Information of the Compound and Protein
Compound Name
 Compound Info 
KIRA analog, 1
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 PubChem ID
CID: 60196244
Canonical SMILES
CC(C)c1nc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)c3ccccc23)c2c(N)nccn12
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Compound Formula C27H23F3N6O
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase/endoribonuclease IRE1
Protein Classification
Enzyme
Uniprot ID
O75460
Gene Name
ERN1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 760 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 290 nM
2 IC50 = 400 nM
3 IC50 = 450 nM