Brief Information of the Compound and Protein
Compound Name
6-chloro-N-(cyclopropylmethyl)-3-(1H-indazol-5-yl)imidazo[1,2-b]pyridazin-8-amine
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PubChem ID
CID: 137333978
Canonical SMILES
Clc1cc(NCC2CC2)c2ncc(-c3ccc4[nH]ncc4c3)n2n1
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Compound Formula C17H15ClN6
Compound Structure
Protein Name
Serine/threonine-protein kinase/endoribonuclease IRE1
Protein Classification
Enzyme
Uniprot ID
O75460
Gene Name
ERN1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 4200 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 303 nM
2 IC50 = 1600 nM
3 IC50 = 8900 nM