Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(2-anilino-3H-benzimidazol-5-yl)-6-chloro-N-[(1-methylpiperidin-4-yl)methyl]imidazo[1,2-b]pyridazin-8-amine
    Show/Hide
 PubChem ID
CID: 155522759
Canonical SMILES
CN1CCC(CNc2cc(Cl)nn3c(cnc23)-c2ccc3[nH]c(Nc4ccccc4)nc3c2)CC1
    Show/Hide
Compound Formula C26H27ClN8
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase/endoribonuclease IRE1
Protein Classification
Enzyme
Uniprot ID
O75460
Gene Name
ERN1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 890 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 90 nM
2 IC50 = 130 nM
3 IC50 = 390 nM