Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10081622, Compound 11
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 PubChem ID
CID: 25141092
SID: 56468453
Canonical SMILES
CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NC2CCOCC2)c1
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Compound Formula C31H34F2N6O2
Compound Structure
Protein Name
 Protein Info 
High affinity nerve growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Trk family
Uniprot ID
P04629
Gene Name
NTRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  3
1
IC50 = 0.22 nM
   TI
   LI
   LO
   TS
2
IC50 = 2.9 nM
   TI
   LI
   LO
   TS
3
IC50 = 45 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1 nM
2 IC50 = 1.7 nM
3 IC50 < 10 nM