Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-[4-(2-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylethyl)pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-one
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 PubChem ID
CID: 138393336
Canonical SMILES
O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC3(CCc4ccccc34)CC2)cn1
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Compound Formula C25H26N6O
Compound Structure
Protein Name
 Protein Info 
Lysine-specific demethylase 4B
Protein Classification
Epigenetic regulator
>
Eraser
>
Lysine demethylase
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Lysine-specific demethylase
Uniprot ID
O94953
Gene Name
KDM4B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 43 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5 nM
2 IC50 = 8 nM
3 IC50 = 12 nM
4 IC50 = 22 nM
5 IC50 = 36 nM
6 IC50 = 62 nM
7 IC50 = 96 nM
8 IC50 = 233 nM
9 IC50 = 382 nM
10 IC50 = 524 nM
11 IC50 = 787 nM