Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-[4-[2-[4-(3-chlorophenyl)-4-methylpiperidin-1-yl]ethyl]pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-one
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 PubChem ID
CID: 138393341
Canonical SMILES
CC1(CCN(CCc2cnn(c2)-c2nccc3c2nc[nH]c3=O)CC1)c1cccc(Cl)c1
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Compound Formula C24H25ClN6O
Compound Structure
Protein Name
 Protein Info 
Lysine-specific demethylase 5B
Protein Classification
Epigenetic regulator
>
Eraser
>
Lysine demethylase
>
Jumonji domain-containing
Uniprot ID
Q9UGL1
Gene Name
KDM5B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 20800 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 14 nM
2 Ki = 2 nM