Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-[4-(2-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylethyl)pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-one
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 PubChem ID
CID: 138393336
Canonical SMILES
O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC3(CCc4ccccc34)CC2)cn1
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Compound Formula C25H26N6O
Compound Structure
Protein Name
 Protein Info 
Lysine-specific demethylase 4A
Protein Classification
Epigenetic regulator
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Methyl-lysine/arginine binding protein
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Tudor domain
Uniprot ID
O75164
Gene Name
KDM4A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 4700 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 15 nM
2 IC50 = 22 nM
3 IC50 = 25 nM
4 IC50 = 39 nM
5 IC50 = 61 nM
6 IC50 = 114 nM
7 IC50 = 197 nM
8 IC50 = 423 nM
9 IC50 = 657 nM
10 IC50 = 857 nM
11 IC50 = 2211 nM
12 Ki = 4 nM