Brief Information of the Compound and Protein
Compound Name
6,7-dimethoxy-2-[(3E)-3-(5-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)propyl]-3,4-dihydro-1H-isoquinoline
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PubChem ID
CID: 24178402
SID: 48410678
Canonical SMILES
COc1cc2CCN(CC\C=C3/CCCc4c(OC)cccc34)Cc2cc1OC
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Compound Formula C25H31NO3
Compound Structure
Protein Name
ATP-dependent translocase ABCB1
Protein Classification
Transporter
>
Primary active transporter
>
ATP-binding cassette
>
ABCB subfamily
Uniprot ID
P08183
Gene Name
ABCB1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000034 Caco-2 Homo sapiens (Human)  1
1
EC50 = 1640 nM
   TI
   LI
   LO
   TS
CL000031 MDCK Canis lupus familiaris (Dog)  3
1
EC50 = 1500 nM
   TI
   LI
   LO
   TS
2
IC50 = 1020 nM
   TI
   LI
   LO
   TS
3
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CL000359 MDCK-MDR1 Canis lupus familiaris (Dog)  1
1
EC50 = 820 nM
   TI
   LI
   LO
   TS