Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[(4-fluorophenyl)methyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide
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 PubChem ID
CID: 118958122
Canonical SMILES
CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccc(F)cc3)[C@@H](C)C(F)(F)F)C2=O)c1
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Compound Formula C25H24F4N4O5
Compound Structure
Protein Name
 Protein Info 
Histone acetyltransferase p300
Protein Classification
Epigenetic regulator
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Bromodomain
Uniprot ID
Q09472
Gene Name
EP300
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 60 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 15 nM
2 IC50 = 60 nM
3 IC50 = 67 nM
4 IC50 ~ 9.8 nM
5 Kd = 13.54 nM
6 Kd ~ 15 nM