Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-[2,4-dichloro-3-[2-cyclopropyl-5-methyl-4-[1-(trifluoromethyl)cyclopropyl]imidazol-1-yl]phenyl]-2-azaspiro[3.3]heptane-6-carboxylic acid
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 PubChem ID
CID: 155539171
Canonical SMILES
Cc1c(nc(C2CC2)n1-c1c(Cl)ccc(N2CC3(CC(C3)C(O)=O)C2)c1Cl)C1(CC1)C(F)(F)F
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Compound Formula C24H24Cl2F3N3O2
Compound Structure
Protein Name
 Protein Info 
Nuclear receptor ROR-gamma
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 1
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Nuclear hormone receptor subfamily 1 group F
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Nuclear hormone receptor subfamily 1 group F member 3
Uniprot ID
P51449
Gene Name
RORC
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000059 HuT 78
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CL000001 Jurkat
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 151 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5 nM