Brief Information of the Compound and Protein
| Compound Name |
2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano-[4,3-d]pyrimidin-4-ol
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PubChem ID | |||||
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Compound Structure |
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| Protein Name |
Poly [ADP-ribose] polymerase tankyrase-1
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Protein Classification |
Enzyme
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Transferase
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| Uniprot ID | Gene Name | TNKS |
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Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000013 | Sf9 | Spodoptera frugiperda (Fall armyworm) | 1 |
| 1 |
IC50 = 4.2 nM
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TI
LI
LO
TS
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|---|---|---|---|
Biochemical Assays
| 1 | IC50 = 1.9 nM | ||
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| 2 | IC50 = 10 nM | ||
| 3 | IC50 = 11 nM | ||
| 4 | IC50 = 11.1 nM | ||
| 5 | IC50 = 13 nM | ||
| 6 | IC50 = 15 nM | ||
| 7 | IC50 = 17 nM | ||
| 8 | IC50 = 68 nM | ||
| 9 | Kd = 100 nM | ||