Brief Information of the Compound and Protein
Compound Name
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
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PubChem ID
CID: 5328940
SID: 14885411
Canonical SMILES
COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl
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Compound Formula C26H29Cl2N5O3
Compound Structure
Protein Name
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
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Other protein kinase group
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Other protein kinase WEE family
Uniprot ID
Q99640
Gene Name
PKMYT1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 133 nM
   TI
   LI
   LO
   TS
2
Ki = 12.7 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 133 nM
2 IC50 = 704 nM
3 Kd = 270 nM
4 Kd = 350 nM
5 Ki = 12.7 nM