Brief Information of the Compound and Protein
Compound Name
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv.
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PubChem ID
CID: 5311382
SID: 14762564
Canonical SMILES
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1
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Compound Formula C26H27Cl2N5O2
Compound Structure
Protein Name
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Protein Classification
Enzyme
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Kinase
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Protein Kinase
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Other protein kinase group
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Other protein kinase WEE family
Uniprot ID
Q99640
Gene Name
PKMYT1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
2
Ki = 0.8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 7 nM
2 IC50 = 8 nM
3 IC50 = 31.1 nM
4 Kd = 247 nM
5 Ki = 0.8 nM