Brief Information of the Compound and Protein
Compound Name
2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(4-(3-hydroxy-2,2-dimethylpropyl)-3-(trifluoromethyl)phenyl)acetamide
    Show/Hide
PubChem ID
CID: 78426332
Canonical SMILES
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(c2)C(F)(F)F)c(F)c1
    Show/Hide
Compound Formula C27H28F4N2O4
Compound Structure
Protein Name
Proto-oncogene tyrosine-protein kinase receptor Ret
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Ret family
Uniprot ID
P07949
Gene Name
RET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000425 TT Homo sapiens (Human)  1
1
IC50 = 9.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.4 nM