Brief Information of the Compound and Protein
Compound Name
4-N-[[4-[(3-fluoropyridin-4-yl)amino]-2-pyridin-2-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]cyclohexane-1,4-diamine
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Canonical SMILES
N[C@H]1CC[C@H](CC1)NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1
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Compound Formula C23H25FN8
Compound Structure
Protein Name
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
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TKL protein kinase group
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TKL protein kinase STKR family
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TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 4.3 nM
   TI
   LI
   LO
   TS