Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-[(1R)-1-[(3,5-difluoro-4-trimethylsilylphenyl)carbamoyl]-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-3,3-dimethyl-5-oxopentanoic acid
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 PubChem ID
CID: 140773958
Canonical SMILES
COc1ccc2[C@@H](N(CCc2c1)C(=O)CC(C)(C)CC(O)=O)C(=O)Nc1cc(F)c(c(F)c1)[Si](C)(C)C
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Compound Formula C27H34F2N2O5Si
Compound Structure
Protein Name
 Protein Info 
Nuclear receptor ROR-gamma
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 1
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Nuclear hormone receptor subfamily 1 group F
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Nuclear hormone receptor subfamily 1 group F member 3
Uniprot ID
P51449
Gene Name
RORC
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000001 Jurkat
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5.6 nM