Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one
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 PubChem ID
CID: 44259
SID: 22395183
Canonical SMILES
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
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Compound Formula C28H26N4O3
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 0.29 nM
   TI
   LI
   LO
   TS
2
IC50 = 47 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.2 nM
2 IC50 = 2.3 nM
3 IC50 = 16.5 nM
4 IC50 = 26.7 nM
5 IC50 = 39.8 nM
6 IC50 = 41 nM
7 IC50 = 44 nM
8 IC50 = 48 nM
9 IC50 = 49 nM
10 IC50 = 58.7 nM
11 IC50 = 74.2 nM
12 IC50 = 78 nM
13 IC50 = 100 nM
14 IC50 = 102.4 nM
15 IC50 = 125 nM
16 IC50 = 132 nM
17 IC50 = 155 nM
18 IC50 = 188.3 nM
19 IC50 = 238 nM
20 IC50 = 283 nM
21 IC50 = 430.57 nM
22 Kd = 0.35 nM
23 Kd = 0.77 nM
24 Kd = 70 nM
25 Kd = 96 nM
26 Kd = 120 nM
27 Kd = 210 nM
28 Kd = 270 nM
29 Kd = 290 nM
30 Kd = 300 nM
31 Kd = 370 nM
32 Kd = 600 nM
33 Kd = 1100 nM