Brief Information of the Compound and Protein
Compound Name
 Compound Info 
CHEBI:63453
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 PubChem ID
CID: 51039095
SID: 136350053
Canonical SMILES
COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
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Compound Formula C26H33N5O3
Compound Structure
Protein Name
 Protein Info 
Fibroblast growth factor receptor 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase FGFR family
Uniprot ID
P11362
Gene Name
FGFR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000434 KG-1
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 < 0.2 nM
   TI
   LI
   LO
   TS
2
IC50 = 16.1 nM
   TI
   LI
   LO
   TS
CL000958 NCI-H1581
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 32.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 62.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.2 nM
2 IC50 = 0.6 nM
3 IC50 = 0.7 nM
4 IC50 = 0.8 nM
5 IC50 = 0.9 nM
6 IC50 = 1.1 nM
7 IC50 = 1.2 nM
8 IC50 = 1.3 nM
9 IC50 = 1.5 nM