Brief Information of the Compound and Protein
Compound Name
(10R)-10-(methylamino)-3-[4-[(2-oxo-3,4-dihydro-1H-quinolin-7-yl)oxy]butyl]-1,3-diazatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-2-one
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PubChem ID
CID: 137649770
Canonical SMILES
CN[C@@H]1Cc2cccc3n(CCCCOc4ccc5CCC(=O)Nc5c4)c(=O)n(C1)c23
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Compound Formula C24H28N4O3
Compound Structure
Protein Name
D(2) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P14416
Gene Name
DRD2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  7
1
EC50 = 104.5 nM
   TI
   LI
   LO
   TS
2
EC50 = 255.3 nM
   TI
   LI
   LO
   TS
3
EC50 = 712.9 nM
   TI
   LI
   LO
   TS
4
EC50 = 1499.7 nM
   TI
   LI
   LO
   TS
5
IC50 = 4102 nM
   TI
   LI
   LO
   TS
6
IC50 > 5000 nM
   TI
   LI
   LO
   TS
7
Ki = 338 nM
   TI
   LI
   LO
   TS