Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3H]pyrilamine
    Show/Hide
 PubChem ID
CID: 4992
SID: 14873190
Canonical SMILES
COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
    Show/Hide
Compound Formula C17H23N3O
Compound Structure
Protein Name
 Protein Info 
Histamine H1 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
P35367
Gene Name
HRH1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
IC50 = 3.3 nM
   TI
   LI
   LO
   TS
2
Ki = 1.6 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 1.259 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  6
1
IC50 = 0.014 nM
   TI
   LI
   LO
   TS
2
IC50 = 1.4 nM
   TI
   LI
   LO
   TS
3
IC50 = 1.9 nM
   TI
   LI
   LO
   TS
4
Ki = 0.71 nM
   TI
   LI
   LO
   TS
5
Ki = 1.7 nM
   TI
   LI
   LO
   TS
6
Ki = 2.089 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 46.77 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 4.467 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.82 nM
2 IC50 = 1.3 nM
3 IC50 = 1.5 nM
4 IC50 = 1.8 nM
5 IC50 = 6.2 nM
6 IC50 = 12.59 nM
7 Ki = 0.95 nM
8 Ki = 2.2 nM