Brief Information of the Compound and Protein
Compound Name
2-chloro-4-[5-cyano-6-[4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-phenylpropanoyl]piperazin-1-yl]pyridin-3-yl]-N,N-dimethylbenzamide
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PubChem ID
CID: 127044456
Canonical SMILES
CN(C)C(=O)c1ccc(cc1Cl)-c1cnc(N2CCN(CC2)C(=O)[C@](O)(c2ccccc2)C(F)(F)F)c(c1)C#N
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Compound Formula C28H25ClF3N5O3
Compound Structure
Protein Name
Oxysterols receptor LXR-alpha
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 1
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Nuclear hormone receptor subfamily 1 group H
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Nuclear hormone receptor subfamily 1 group H member 3
Uniprot ID
Q13133
Gene Name
NR1H3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 45 nM
   TI
   LI
   LO
   TS