Brief Information of the Compound and Protein
Compound Name
(2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1-ethyl-2-iodoimidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
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PubChem ID
CID: 127032875
Canonical SMILES
CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I
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Compound Formula C18H25IN6O4
Compound Structure
Protein Name
Thyrotropin-releasing hormone receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Neuropeptide receptor
Uniprot ID
Q9ERT1
Gene Name
TRH-R2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
EC50 = 0.1 nM
   TI
   LI
   LO
   TS
2
EC50 = 4 nM
   TI
   LI
   LO
   TS
3
IC50 = 2450 nM
   TI
   LI
   LO
   TS