Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione
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 PubChem ID
CID: 3822
SID: 12013738
Canonical SMILES
Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
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Compound Formula C22H22FN3O3
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 2A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P28223
Gene Name
HTR2A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
2
IC50 = 80 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
EC50 = 1.04 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.35 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.52 nM
   TI
   LI
   LO
   TS
4
IC50 = 83.7 nM
   TI
   LI
   LO
   TS
5
Ki = 0.28 nM
   TI
   LI
   LO
   TS
6
Ki = 0.3 nM
   TI
   LI
   LO
   TS
7
Ki = 10.7 nM
   TI
   LI
   LO
   TS
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  2
1
Ki = 0.23 nM
   TI
   LI
   LO
   TS
2
Ki = 0.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.77 nM
2 IC50 = 0.82 nM
3 IC50 = 0.9 nM
4 IC50 = 2.5 nM
5 IC50 = 2.6 nM
6 IC50 = 13 nM
7 IC50 = 14 nM
8 IC50 = 32 nM
9 Ki = 0.28 nM
10 Ki = 0.45 nM
11 Ki = 0.49 nM
12 Ki = 1.3 nM