Brief Information of the Compound and Protein
Compound Name
Cb 5083
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PubChem ID
CID: 73051434
Canonical SMILES
Cc1cc2c(cccc2n1-c1nc2CCOCc2c(NCc2ccccc2)n1)C(N)=O
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Compound Formula C24H23N5O2
Compound Structure
Protein Name
Transitional endoplasmic reticulum ATPase
Protein Classification
Transporter
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Primary active transporter
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Endoplasmic reticular retrotranslocon family
Uniprot ID
P55072
Gene Name
VCP
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  3
1
IC50 = 490 nM
   TI
   LI
   LO
   TS
2
IC50 = 680 nM
   TI
   LI
   LO
   TS
3
IC50 = 1030 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 11 nM
2 IC50 = 27 nM
3 IC50 = 44 nM
4 Ki = 26.1 nM