Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(1R,2S,4R,5R,6R)-2-amino-4-[[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
    Show/Hide
 PubChem ID
CID: 71137010
Canonical SMILES
N[C@]1(C[C@@H](Sc2nnc([nH]2)C(F)(F)F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
    Show/Hide
Compound Formula C11H11F3N4O4S
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 3
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
Q14832
Gene Name
GRM3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000125 MCB3901
 Cell Line Info 
Mesocricetus auratus (Golden hamster)  4
1
EC50 = 79.5 nM
   TI
   LI
   LO
   TS
2
EC50 = 82 nM
   TI
   LI
   LO
   TS
3
IC50 = 528 nM
   TI
   LI
   LO
   TS
4
Ki = 56.7 nM
   TI
   LI
   LO
   TS