Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
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 PubChem ID
CID: 53240406
SID: 124354482
Canonical SMILES
N[C@]1(C[C@@H](Sc2nnc[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
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Compound Formula C10H12N4O4S
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 3
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
Q14832
Gene Name
GRM3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000125 MCB3901
 Cell Line Info 
Mesocricetus auratus (Golden hamster)  9
1
EC50 = 129 nM
   TI
   LI
   LO
   TS
2
EC50 = 1175 nM
   TI
   LI
   LO
   TS
3
EC50 = 2181 nM
   TI
   LI
   LO
   TS
4
EC50 = 2831 nM
   TI
   LI
   LO
   TS
5
EC50 = 5676 nM
   TI
   LI
   LO
   TS
6
EC50 > 25000 nM
   TI
   LI
   LO
   TS
7
IC50 = 2730 nM
   TI
   LI
   LO
   TS
8
IC50 = 25200 nM
   TI
   LI
   LO
   TS
9
Ki = 156 nM
   TI
   LI
   LO
   TS