Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

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PubChem ID

CID: 213056

SID: 14748421

Canonical SMILES	N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O Show/Hide
Compound Formula	C8H11NO4

Compound Structure

Protein Name

Protein Info

Metabotropic glutamate receptor 2

Protein Classification

Membrane receptor

Family C G protein-coupled receptor

Small molecule receptor (family C GPCR)

Neurotransmitter receptor (family C GPCR)

Metabotropic glutamate receptor

Uniprot ID

Q14416

Gene Name

GRM2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 7 nM	TI LI LO TS
2	Ki = 71.7 nM	TI LI LO TS
CL000125	MCB3901 Cell Line Info	Mesocricetus auratus (Golden hamster)	4
1	EC50 = 7 nM	TI LI LO TS
2	EC50 = 34.4 nM	TI LI LO TS
3	IC50 = 5.6 nM	TI LI LO TS
4	Ki = 71.7 nM	TI LI LO TS

Biochemical Assays