Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[3-[4-(1H-indazol-3-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl]oxyphenyl]prop-2-enamide
    Show/Hide
 PubChem ID
CID: 122186150
Canonical SMILES
CN1CCN(CC1)c1cc(Nc2n[nH]c3ccccc23)nc(Oc2cccc(NC(=O)C=C)c2)n1
    Show/Hide
Compound Formula C25H26N8O2
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  5
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
2
IC50 = 500 nM
   TI
   LI
   LO
   TS
3
IC50 = 1700 nM
   TI
   LI
   LO
   TS
4
Ki = 0.32 nM
   TI
   LI
   LO
   TS
5
Ki = 833 nM
   TI
   LI
   LO
   TS