Brief Information of the Compound and Protein
Compound Name
3-amino-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(2,5-dibromo-1H-imidazol-4-yl)-1-oxopropan-2-yl)pyrazine-2-carboxamide
    Show/Hide
PubChem ID
CID: 122185155
Canonical SMILES
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(Br)[nH]c1Br)NC(=O)c1nccnc1N
    Show/Hide
Compound Formula C16H18Br2N8O3
Compound Structure
Protein Name
Thyrotropin-releasing hormone receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Neuropeptide receptor
Uniprot ID
Q9ERT1
Gene Name
TRH-R2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
2
IC50 > 50000 nM
   TI
   LI
   LO
   TS