Brief Information of the Compound and Protein
Compound Name
N-[5-(2-chlorobenzoyl)-4-(3-chlorophenyl)-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)acetamide
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PubChem ID
CID: 56837193
SID: 134966686
Canonical SMILES
CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2Cl)-c2cccc(Cl)c2)cc1
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Compound Formula C26H20Cl2N2O4S2
Compound Structure
Protein Name
Nuclear receptor ROR-gamma
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 1
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Nuclear hormone receptor subfamily 1 group F
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Nuclear hormone receptor subfamily 1 group F member 3
Uniprot ID
P51449
Gene Name
RORC
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000789 HG5LN Homo sapiens (Human)  1
1
IC50 = 80 nM
   TI
   LI
   LO
   TS
CL000001 Jurkat Homo sapiens (Human)  1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 7.943 nM
2 IC50 = 9 nM
3 IC50 = 15.85 nM
4 IC50 = 22 nM
5 Ki = 39.81 nM