Brief Information of the Compound and Protein
Compound Name
2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-isoindole-1,3-dione
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PubChem ID
CID: 4431
SID: 14854322
Canonical SMILES
COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1
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Compound Formula C23H27N3O3
Compound Structure
Protein Name
5-hydroxytryptamine receptor 1A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Serotonin receptor
Uniprot ID
P08908
Gene Name
HTR1A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  3
1
IC50 = 4.73 nM
   TI
   LI
   LO
   TS
2
IC50 = 5 nM
   TI
   LI
   LO
   TS
3
Ki = 87 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  2
1
Ki = 0.6 nM
   TI
   LI
   LO
   TS
2
Ki = 4.49 nM
   TI
   LI
   LO
   TS