Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)benzenesulfonamide
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 PubChem ID
CID: 3693566
SID: 14813987
Canonical SMILES
COc1cc(OC)c(cc1N[S](=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O
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Compound Formula C27H31F3N4O7S
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 2C
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P28335
Gene Name
HTR2C
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 1.995 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 1.5 nM
   TI
   LI
   LO
   TS
2
Ki = 0.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.7 nM
2 IC50 = 5.5 nM
3 IC50 = 8.3 nM
4 Ki = 0.91 nM
5 Ki = 3.9 nM