Brief Information of the Compound and Protein
Compound Name
[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone
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PubChem ID
CID: 11427553
SID: 16524833
Canonical SMILES
O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1
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Compound Formula C20H20N4O
Compound Structure
Protein Name
Receptor-type tyrosine-protein kinase FLT3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P36888
Gene Name
FLT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000408 MOLM-14 Homo sapiens (Human)  1
1
IC50 = 14.8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.6 nM
2 IC50 = 13.1 nM
3 Kd = 6.6 nM
4 Kd = 13 nM
5 Kd = 15 nM
6 Kd = 20 nM
7 Kd = 60 nM