Brief Information of the Compound and Protein
| Compound Name |
16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one
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PubChem ID | |||||
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Compound Structure |
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| Protein Name |
Receptor-type tyrosine-protein kinase FLT3
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Protein Classification |
Enzyme
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Kinase
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Protein Kinase
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TK protein kinase group
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Tyrosine protein kinase PDGFR family
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| Uniprot ID | Gene Name | FLT3 |
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Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Biochemical Assays
| 1 | IC50 = 3 nM | ||
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| 2 | IC50 = 5 nM | ||
| 3 | IC50 = 8.2 nM | ||
| 4 | Kd = 0.57 nM | ||
| 5 | Kd = 0.66 nM | ||
| 6 | Kd = 1.4 nM | ||
| 7 | Kd = 1.5 nM | ||
| 8 | Kd = 5.4 nM | ||
| 9 | Kd = 7 nM | ||
| 10 | Kd = 8.5 nM | ||